Since four CAD mammographic systems have received FDA approval in the United States. The pioneer was the ImageChecker of R2 Technologies Inc. [148]. In January two new CADs were approved: the CADx Second Look and the iCAD MammoReader [77]. However, these two companies are now merged1.1, and only the Second Look is still available. Finally, the last one to join this selected group has been the Kodak Mammography CAD Engine [93], in . However, it is almost sure that more commercial CADs will be available in the near future.